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September 10, 2025Journal of Neurosciences in Rural PracticeOpen Access

Is depression modulating brain metabolism in migraine? Insights from proton magnetic resonance spectroscopy of the left dorsolateral prefrontal cortex

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Authors

BRBhavika RaiVDVishal DhimanRGRavi Gupta

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Overview

Observational analysis reveals no metabolite level differences in the left dorsolateral prefrontal cortex between migraine patients with and without depression, suggesting shared neurometabolic profiles.

Key Points

  • No significant differences in left dorsolateral prefrontal cortex metabolite levels were found between migraine patients with and without depression.
  • Mean N-acetyl aspartate/total creatine ratio was 1.79 in both groups, showing no variation between them.
  • Observational analysis compared brain metabolite levels in migraine patients using proton magnetic resonance spectroscopy.
  • These findings highlight potential sample size limitations and call for further studies to explore the DLPFC’s neuromodulation potential.

Cite This Study

Rai et al. (2025) studied this question.

synapsesocial.com/papers/68c1a13a54b1d3bfb60dca08https://doi.org/10.25259/jnrp_191_2025
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