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May 17, 2026Cephalalgia

Magnetic resonance spectroscopy during migraine attacks: A systematic review

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Authors

DRDelia-Ioana RadutiuESEdina SzabóRCRune Häckert Christensen

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Overview

Systematic review examines neurochemical changes during migraine attacks, suggesting altered brain metabolism.

Key Points

  • This review aims to summarize the evidence on neurochemical and metabolic changes observed during migraine attacks using MRS.
  • Conducted a systematic review per PRISMA standards, registered in PROSPERO.
  • Analyzed studies using 1 H-MRS or 31 P-MRS during migraine attacks, with comparisons to non-ictal states or healthy controls.
  • Performed qualitative analysis due to variability in designs and outcomes across included studies.
  • Eight studies from 1988 to 2022 included, with five using 1 H-MRS and three using 31 P-MRS.
  • 1 H-MRS studies revealed increases in total choline and N-acetyl aspartate during migraines, along with decreased glutathione.
  • 31 P-MRS indicated changes in cerebral energy metabolism during migraine attacks.

Cite This Study

Radutiu et al. (2026) studied this question.

synapsesocial.com/papers/6a095b1b7880e6d24efe0d86https://doi.org/10.1177/03331024261441576
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