Background: The split-mouth randomized clinical trial evaluated and compared the clinical efficacy and patient-centered outcomes of platelet-rich fibrin (PRF) combined with modified coronally advanced flap (MCAF) and minimally invasive coronally advanced flap (MICAF) techniques for the treatment of multiple adjacent gingival recession (GR) Cairo's RT1 and/or RT2. Methods: Eighteen participants with multiple GR defects were treated using MCAF + PRF and MICAF + PRF approaches in a split-mouth design. A qualified periodontist examined the periodontal clinical parameters (recession height RH recession width RW, clinical attachment level CAL gain, probing depth PD, keratinized tissue width KTW, and gingival thickness GT) and aesthetics at baseline and 6 months later. After 7 days, 3 months, and 6 months, patient-centered outcomes relating to pain/discomfort and aesthetics were evaluated using a visual analog scale (VAS) and a questionnaire. A statistical study was performed on the variations between the original recording and the subsequent months. Results: Both the surgical methods showed statistically significant improvements in all clinical parameters, such as RH, RW, CAL, PD, and KTW (p < 0.001). MICAF + PRF was found to have a similar clinical efficacy to MCAF + PRF for tissue gain; yet between-group differences in GT after 6 months were not statistically significant. Patient-related outcome measures (PROMs) were significantly better in MICAF + PRF with lower VAS pain scores (p < 0.001) and higher ratings of esthetic satisfaction (p < 0.001) at 6 months' follow-up. Trial Registration: Name of the Registry: Clinical Trials Registry - India (CTRI); Registration Number: CTRI/2019/01/016994.
Daga et al. (Wed,) studied this question.