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September 10, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Investigation of the inhibitory effects of total flavonoids of litchi seed on Clonorchis sinensis-induced liver damage and fibrosis

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Authors

LLLiuchun LuoGuangxi Medical UniversityJWJilong WangAnhui Jianzhu UniversityQCQiuchen ChengThe People's Hospital of Guangxi Zhuang Autonomous Region

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Overview

Animal experiments show that total flavonoids of litchi seed reduce liver fibrosis in rats infected with clonorchis sinensis, suggesting new therapeutic options.

Key Points

  • TFL significantly improved liver function in rats infected with clonorchis sinensis, reducing liver damage markers.
  • Rats treated with TFL showed decreased levels of hepatic stellate cells, indicating a reduction in liver fibrosis.
  • The study revealed that TFL downregulated fibrosis-related markers such as collagen I and α-SMA in liver tissues.
  • Experimental data supports the potential for TFL as a novel treatment for liver fibrosis induced by clonorchis sinensis.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/68c1a13a54b1d3bfb60dcb6ahttps://doi.org/10.3389/fcimb.2025.1625004
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Also Consider

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  1. 1A systematic review of the effects of hepatitis B and C virus on the progression of liver fluke infection to liver cancer2024 · 7 citations
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  3. 3FXR in liver physiology: Multiple faces to regulate liver metabolism2021 · 163 citations