What type of study is this?

This is a Retrospective cohort study study.

September 10, 2025Frontiers in OncologyOpen Access

Demographics, risk factors associated with malignant progression, and pregnancy outcomes of hydatidiform mole: A retrospective cohort study in Shanghai, China

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Retrospective cohort study evaluates risk factors and pregnancy outcomes in patients with hydatidiform mole, indicating predictive model efficacy.

Of 506 hydatidiform mole patients, 42 (8.3%) progressed to gestational trophoblastic neoplasia, all achieving complete response after treatment.
A predictive model using age and ultrasound characteristics showed optimal performance for identifying risk factors for progression to pGTN.
Demographics revealed an average age of 33 years among patients with hydatidiform mole at diagnosis, with successful re-pregnancy in 64.2%.
Risk factors identified include pathological type and maximum diameter of lesions, both significant for predicting malignant progression.

Zhu et al. (2025) studied this question.

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Retrospective cohort study evaluates risk factors and pregnancy outcomes in patients with hydatidiform mole, indicating predictive model efficacy.