This reaction shows selective synthesis of imidazoles and imidazolones using sulfur ylides and isonitrile, suggesting pathway control via isocyanide structure.
A base-mediated three-component reaction has been developed to selectively synthesize polysubstituted 2-imidazolones and imidazoles from sulfur ylides, nitrosobenzene, and isonitrile under mild, catalyst-free conditions. The reaction pathway can be controlled by modifying the structure of the active isocyanide. Plausible mechanisms have been proposed to explain the observed reactivity.
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Xiang et al. (2025) studied this question.
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