This review highlights the roles of inhibitory neurons from the caudal ganglionic eminence, implying their importance in neurodevelopmental diseases.
In the brain, maintaining the appropriate levels of excitation and inhibition is required for proper cognitive function. Inhibitory neurons, essential for maintaining this balance and implicated in various neurodevelopmental diseases, are generated during embryonic development from the ganglionic eminences (GEs). This review discusses the importance of inhibitory neuronal subtypes generated from the most posterior GE subregion, the caudal ganglionic eminence (CGE), highlighting what is known about their developmental origins, diversity, and functions in mice, humans, and non-human primates. By reviewing the molecular composition and patterning of the CGE, we discuss how technological advances have provided insights into the spatial heterogeneity of progenitor populations and the distinctive molecular characteristics and functions of CGE-derived neurons.
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Horton et al. (2025) studied this question.
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