Case study demonstrates effective localization of parathyroid lesions in a patient with MEN 1 syndrome, indicating potential for advanced imaging techniques.
Less than 10% of primary hyperparathyroidism (PHPT) patients have supernumerary parathyroid glands. In a 52-year-old man with multiple endocrine neoplasia type 1 (MEN 1) syndrome with PHPT, integrated 18 F-Fluorocholine PET/4D-CT (FCH PET/4D-CT) was done for localization of parathyroid adenoma. FCH PET/4D-CT revealed 5 culprit lesions (1 ectopic) along with FCH avid nonenhancing anterior mediastinal mass, possibly NET or thymoma. FNAC of the mass raised a suspicion of NET, which was corroborated by subsequent 68 Ga-DOTANOC PET/CT. Parathyroidectomy for all 5 glands and thymic mass excision was done. Histopathology confirmed 5 hyperplastic parathyroid lesions and a well-differentiated thymic NET. Intact PTH and calcium levels were normalized postsurgery.
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Dharmashaktu et al. (2025) studied this question.
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