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September 10, 2025Frontiers in Behavioral NeuroscienceOpen Access

Neural mechanisms of maladaptive risk decision-making across psychiatric disorders

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Authors

CLCheng‐Han LinYWYuhui WangWXWenjie Xia

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Overview

Systematic review reveals frontostriatal dysregulation and disorder-specific neural signatures in risk decision-making.

Key Points

  • Frontostriatal dysregulation features prefrontal hypoactivation and striatal hyperreactivity, especially notable in bipolar disorder.
  • Distinct neural signatures in anxiety, depression, and schizophrenia highlight how different psychiatric disorders influence risk decision-making.
  • Computational modeling indicates altered risk sensitivity and loss aversion across various psychiatric conditions.
  • Future research should integrate computational psychiatry with multimodal biomarkers to improve clinical applications.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68c1a26154b1d3bfb60dd3fbhttps://doi.org/10.3389/fnbeh.2025.1637582
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