Case report shows recurrence-free survival in a patient with pulmonary lymphoepithelioma-like carcinoma, suggesting chemoradiotherapy may be effective.
Pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small cell lung cancer (NSCLC) that is closely associated with Epstein-Barr virus (EBV) infection. While radiotherapy after induction chemotherapy have shown marked efficacy in nasopharyngeal carcinoma (NPC), its effectiveness in pLELC remains uncertain. A female with stage IIIB pLELC was treated with 4 cycles of gemcitabine plus cisplatin, achieving partial response(PR), followed by radical radiotherapy. Patients achieved clinical complete response(CR) with recurrence-free for over five years. This case highlights the potential of induction chemotherapy as an effective treatment for locally advanced pLELC.
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Huang et al. (2025) studied this question.
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