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September 10, 2025Frontiers in Cell and Developmental BiologyOpen Access

Integrated analysis of miRNAs-mRNAs in skeletal muscle development revealed that novel-miR-766 affects myoblast differentiation and myofiber-type formation in sheep

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Authors

ZGZhenzhen GuWDWeixun DuanCLChenxi Liu

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Overview

Analysis reveals novel-miR-766 affects myoblast differentiation and myofiber types in sheep, indicating its critical role in muscle development.

Key Points

  • Novel-miR-766 significantly influences myoblast differentiation and myofiber-type formation in sheep muscle.
  • Differential expression identified 284 miRNAs, with key roles in myofiber formation and growth across 11 gestation periods.
  • Whole-transcriptome sequencing and functional assays established novel-miR-766's regulatory impact on MYH3 and myoblast functions.
  • This research clarifies miRNA expression patterns, enhancing understanding of skeletal muscle development in sheep.

Cite This Study

Gu et al. (2025) studied this question.

synapsesocial.com/papers/68c1a26154b1d3bfb60dd44bhttps://doi.org/10.3389/fcell.2025.1615676
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