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September 10, 2025HematologyOpen Access

Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study

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Authors

CLChaoqun LuMWMinghui WangLJLi Jiang

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Overview

Mendelian randomization reveals associations between inflammatory proteins and hematologic malignancies, suggesting drug targets.

Key Points

  • Circulating inflammatory proteins exhibit both positive and negative associations with hematologic malignancies.
  • Nine identified proteins may serve as potential cross-cancer drug targets for therapeutic intervention.
  • A two-sample Mendelian randomization study utilized data from 91 proteins and 11 types of hematologic malignancies.
  • The findings support a causal relationship between inflammatory proteins and the risk of developing blood malignancies.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/68c1a26154b1d3bfb60dd49ahttps://doi.org/10.1080/16078454.2025.2538327
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