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March 1, 2026MedicineOpen Access

The causal effect of cytokine cycling levels on the risk of cervical cancer: A bidirectional 2-sample Mendelian randomization study

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Authors

ZGZiqi GeCZCuilin ZhangZZZili Zhang

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Overview

Mendelian randomization analysis assesses inflammatory proteins' impact on cervical cancer risk, suggesting new intervention avenues.

Key Points

  • To investigate the causal relationship between levels of cytokines and the risk of cervical cancer using 2-sample Mendelian randomization.
  • Conducted a 2-sample Mendelian randomization analysis using genetic variants as instrumental variables.
  • Analyzed data from 14,824 individuals, including 909 cervical cancer cases and 238,249 controls.
  • Utilized multiple analysis methods, including random effect inverse variance weighted and MR-Egger.
  • Performed sensitivity analysis to assess robustness of findings.
  • C-C motif chemokine ligand 19 (CCL19) and interleukin-12 (IL-12) were found to significantly increase cervical cancer risk.
  • Monocyte chemotactic protein-3 (MCP-3) was associated with a protective effect against cervical cancer.
  • CCL19 had an odds ratio of 1.479, and IL-12 had an odds ratio of 1.171, both indicating increased risk.
  • The findings were consistent across sensitivity analysis methods.

Cite This Study

Ge et al. (2026) studied this question.

synapsesocial.com/papers/69a3d8caec16d51705d2ff25https://doi.org/10.1097/md.0000000000047782
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Investigating the causal linkages between circulating inflammatory proteins and breast cancer risk and prognosis: Insights from a two-sample Mendelian randomization analysis2026
  2. 2Association between inflammatory cytokines and prostate cancer2024
  3. 3Limited evidence for causal effects of circulating inflammatory cytokines on the risk of selected hematologic malignancies: a two-sample Mendelian randomization study2026
  4. 4Exploring causal correlations between circulating levels of cytokines and colorectal cancer risk: A Mendelian randomization analysis2024 · 9 citations
  5. 5Investigating bidirectional causality between prostate cancer and inflammatory factors: A 2-sample Mendelian randomization analysis2025