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September 10, 2025Drug Design Development and TherapyOpen Access

Comparative Analysis of Pioglitazone and Tirzepatide on Body Weight, Glucose Levels, Neuroinflammation, and Oxidative Stress in Diabetic Rats

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Authors

AAAhmad AlhowailMAMohammed F. AldawsariMAMaha A. Aldubayan

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Overview

Comparative analysis reveals pioglitazone outperforms tirzepatide on glucose levels and neuroinflammation in diabetic rats.

Key Points

  • Diabetes reduced survival rates and increased neuroinflammation, impacting cognitive function in rats.
  • Pioglitazone decreased glucose levels and oxidative stress more significantly than tirzepatide in diabetic models.
  • Neuroprotective effects were noted for both drugs, with improvements in cognitive behavior assessments observed.
  • This analysis highlights the potential of pioglitazone as a superior treatment option for managing T2DM.

Cite This Study

Alhowail et al. (2025) studied this question.

synapsesocial.com/papers/68c1a26154b1d3bfb60dd4b9https://doi.org/10.2147/dddt.s525690
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