SsrA-based design of BacPROTAC for β-lactamase degradation in Gram-negative bacteria

Qichang Nie; Jiannan Wu; Kun Zhang; Shili Lin; Carmen Oi Kwan Law; Ying Ying Zhang; Xiutong Wang; Yanjuan Gu; Zhongping Yao; Wing‐Tak Wong; Terrence Chi‐Kong Lau

doi:10.1039/d5cc02015h

January 1, 2025Chemical Communications

SsrA-based design of BacPROTAC for β-lactamase degradation in Gram-negative bacteria

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Key Points

SsrA-based BacPROTACs effectively restore cefotaxime efficacy by degrading CTX-M-14 β-lactamase.
The approach utilizes the ClpXP protease, enhancing the controllability of bacterial protein degradation.
This method highlights a promising strategy for overcoming antibiotic resistance in gram-negative bacteria.
Effective degradation of β-lactamase improves therapeutic options against resistant infections.

Implication

SsrA-based BacPROTACs restore cefotaxime efficacy in Gram-negative bacteria, suggesting a new approach for protein elimination.

Abstract

SsrA-based BacPROTACs leverage ClpXP protease to degrade the CTX-M-14 β-lactamase, restoring cefotaxime efficacy and enabling controllable bacterial protein elimination.

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Cite This Study

Nie et al. (2025) studied this question.

synapsesocial.com/papers/68c1a26954b1d3bfb60ddab8 https://doi.org/10.1039/d5cc02015h

View Full Paper

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SsrA-based design of BacPROTAC for β-lactamase degradation in Gram-negative bacteria

Key Points

Implication

Abstract

Discussion

Cite This Study

SsrA-based design of BacPROTAC for β-lactamase degradation in Gram-negative bacteria

Key Points

Implication

Abstract

Discussion

Cite This Study

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