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September 10, 2025Journal of Heterocyclic Chemistry

I2‐Mediated Mild Synthesis of Benzothiadiazine 1,1‐Dioxide Derivatives From Aminobenzamides and Aldehydes

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Authors

DHDongxiao HeYZYu ZhouYWYue Wu

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Overview

This method demonstrates the oxidative cyclization of aminobenzamides with aldehydes, highlighting an eco-friendly approach.

Key Points

  • An environmentally friendly method yields benzothiadiazine derivatives effectively and simply.
  • Using molecular iodine as the oxidant, moderate to good yields were achieved with various substrates.
  • The protocol provides a straightforward one-pot synthesis of benzothiadiazine 1,1-dioxide derivatives.
  • The approach eliminates the need for transition metals, enhancing sustainability in synthesizing organic compounds.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68c1a27254b1d3bfb60ddc2ehttps://doi.org/10.1002/jhet.70049
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