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This method demonstrates the oxidative cyclization of aminobenzamides with aldehydes, highlighting an eco-friendly approach.
An environmentally benign and transition metal‐free oxidative cyclization method has been developed for the one‐pot synthesis of benzothiadiazine 1,1‐dioxide derivatives, utilizing molecular iodine (I 2 ) as the sole oxidant from commercially available aldehydes and 2‐aminobenzenesulfonamides. The protocol features a wide substrate scope and simple operation, providing easy access to a range of benzothiadiazine 1,1‐dioxide derivatives in moderate to good yields.
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He et al. (2025) studied this question.
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