The Role of Intestinal Microbiota in the Development of Cardiovascular Pathology

Relevance: еhis article examines the role of intestinal microbiota and its metabolites in the development of cardiovascular disease. Despite known classical risk factors, morbidity and mortality from cardiovascular diseases remain high, which emphasizes the need to study new pathogenetic mechanisms, including the influence of gut microflora disorders. Key microbiota metabolites such as trimethylamine-N-oxide, short-chain fatty acids, and lipopolysaccharides involved in the development of atherosclerosis, coronary heart disease, chronic heart failure, and arterial hypertension are reviewed. In intestinal dysbiosis, there is a decrease in the diversity of microbiota species, which contributes to the development of inflammatory processes, increased oxidative stress and decreased protective function of the intestinal barrier. These disorders, in turn, negatively affect the course of cardiovascular diseases, including aggravating their progression. Conclusion: ьodern studies confirm that the composition of intestinal microbiota and its metabolites can serve as new biomarkers for diagnostics and prognosis of cardiovascular diseases. The development of methods for correction of microbiota composition disorders aimed at modulation of microbial metabolic pathways are promising directions. Individual approach to dysbiosis correction opens new opportunities for personalized prevention and treatment of cardiovascular diseases.