An Uncommon Reaction to a Common Medication: Stevens-Johnson Syndrome Associated With Azithromycin

Stevens-Johnson Syndrome (SJS) is a rare but potentially fatal skin reaction characterized by extensive involvement of the epidermal and mucosal tissue. Although medications are the typical culprits, infectious diseases and chronic illnesses may also trigger SJS or toxic epidermal necrolysis (TEN). We present a rapid, severe SJS/TEN case in response to azithromycin administration, underscoring the critical need for pharmacovigilance and discontinuation of suspected medications, even if the potential causative agent is not commonly associated with these severe cutaneous adverse reactions.