What type of study is this?

This is a Observational study (also classified as: Animal Study).

September 10, 2025PharmaceuticalsOpen Access

Integration of Untargeted Metabolomics, Network Pharmacology, Single-Cell RNA Sequencing, and Molecular Dynamics Simulation Reveals GOT1, CYP1A2, and CA2 as Potential Targets of Huang Qin Decoction Preventing Colorectal Cancer Liver Metastasis

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Integration reveals potential targets GOT1, CYP1A2, and CA2 in colorectal cancer treatment, suggesting significant metabolic regulation.

Significant alterations in metabolite profiles indicate metabolic reprogramming during colorectal cancer progression.
Network pharmacology identified HQD's regulatory influence on metabolic pathways targeting GOT1, CYP1A2, and CA2.
Single-cell RNA sequencing analysis suggests HQD enhances cytotoxic T cell functionality, impacting the tumor microenvironment.
Cellular experiments confirmed the inhibitory effects of naringenin on CRC cells by targeting GOT1 and disrupting metabolism.

Li et al. (2025) studied this question.

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