What type of study is this?

This is a In Vitro Study study.

September 10, 2025Fluids and Barriers of the CNSOpen Access

Identifying a potential role of immune cells in gadolinium deposition within the brain

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Authors

DPDixy ParakkattelUniversity of Bern NRNico O. RuprechtUniversity of Bern PBPeter BroekmannUniversity of Bern

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Implication

Investigative study shows immune cells transport gadolinium-based contrast agents across the BBB, suggesting potential implications for Gd deposition.

Key Points

Immune cells can transport gadolinium-based contrast agents across the BBB, contributing to Gd deposition.
Experiments demonstrated that T cells and monocytes can extravasate similarly to non GBCA loaded cells.
Flow cytometry analysis validated adhesion molecule expression profiles on immune cells involved in Gd transport.
The study employed an in vitro BBB model that simulates physiological conditions to observe immune cell behavior.

Cite This Study

Parakkattel et al. (2025) studied this question.

synapsesocial.com/papers/68c1a3f954b1d3bfb60de1e4 https://doi.org/10.1186/s12987-025-00674-5

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Implication

Investigative study shows immune cells transport gadolinium-based contrast agents across the BBB, suggesting potential implications for Gd deposition.

Identifying a potential role of immune cells in gadolinium deposition within the brain

Discussion

Member takes

Implication

Key Points

Cite This Study

Identifying a potential role of immune cells in gadolinium deposition within the brain

Discussion

Member takes

Implication

Key Points

Cite This Study

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