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September 10, 2025Nature CommunicationsOpen Access

Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis

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Authors

TLTze Mun LooJapanese Foundation For Cancer Research XZXiangyu ZhouWeifang Medical University YTYôko TanakaKanazawa University

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Implication

Observational analysis reveals that lysosomal dysfunction reduces ferroptosis sensitivity in senescent cells, suggesting therapeutic implications for age-related diseases.

Key Points

Ferroptosis resistance in senescent cells is linked to lysosomal dysfunction, preventing lipid peroxidation.
Lysosomal alkalinization causes retention of ferrous iron, contributing to ferroptosis resistance.
Treatment with the V-ATPase activator EN6 restores lysosomal acidity, enhancing ferroptosis sensitivity.
The mechanism of ferroptosis resistance observed in senescent cells also appears in pancreatic cancer models.

Cite This Study

Loo et al. (2025) studied this question.

synapsesocial.com/papers/68c1a3f954b1d3bfb60de1ee https://doi.org/10.1038/s41467-025-61894-9

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Implication

Observational analysis reveals that lysosomal dysfunction reduces ferroptosis sensitivity in senescent cells, suggesting therapeutic implications for age-related diseases.

Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis

Discussion

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Implication

Key Points

Cite This Study

Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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