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September 10, 2025mSystemsOpen Access

HIV-1 Vpu interacts with RBM10 to promote HIV-1 infection

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Authors

BLBoye LiYHYanzhe HaoXMXianbin Meng

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Overview

This analysis demonstrates how Vpu promotes HIV-1 replication through interactions with RBM10, regulating viral and host RNA expression.

Key Points

  • The interaction between Vpu and RBM10 leads to RBM10 degradation, increasing viral replication.
  • This study identified RBM10 as a novel regulator affecting HIV-1 transcription and infection.
  • Mass spectrometry methods revealed multiple host targets of Vpu, enriching pathways related to RNA transport.
  • Understanding Vpu's influence on RNA replication contributes to novel antiviral strategies against HIV-1.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1a40954b1d3bfb60de621https://doi.org/10.1128/msystems.00403-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages2024 · 10 citations
  2. 2MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages2023 · 9 citations
  3. 3Characterization of HIV-1 vpu Gene from Suppressed Viremic Older Individuals with HIV on Long-Term Antiretroviral Therapy2026
  4. 4HIV-2 glycoproteins upregulate microRNAs 25 and 93 to counter the MARCH1 antiviral effect in macrophages2025
  5. 5HIV-2 glycoproteins upregulate microRNAs 25 and 93 to counter the MARCH1 antiviral effect in macrophages2025