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September 29, 2023mBioOpen Access

MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages

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Authors

RLRobert LodgeZXZaikun XuMEMckenna Eklund

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Overview

Randomized trial shows Vpu induces microRNAs to enhance HIV-1 infectivity in macrophages, suggesting new therapeutic targets.

Key Points

  • This research investigates how HIV-1's Vpu protein counteracts MARCH1-mediated restriction on viral infectivity in macrophages.
  • Evaluated the role of Vpu in increasing microRNAs-25 and -93 levels targeting MARCH1 mRNA.
  • Assessed the recruitment of β-TRCP and its effect on β-catenin levels.
  • Utilized pharmacological targeting of the β-catenin pathway to analyze its impact on microRNA induction.
  • Vpu increased levels of microRNAs-25 and -93, leading to downregulation of MARCH1 mRNA.
  • Inhibition of the β-catenin pathway blocked Vpu's microRNA induction and restored MARCH1 activity.
  • MARCH1 reduced surface expression of HIV-1 Env, limiting viral infectivity.

Cite This Study

Lodge et al. (2023) studied this question.

synapsesocial.com/papers/6a6ffbdd26770c2b8de042eehttps://doi.org/10.1128/mbio.01950-23
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