Association of Hyperuricemia and Albuminuria with Presence of Cardiovascular Complications Among Patients of Type-II Diabetes Mellitus

Objective: To look for association of hyperuricemia, albuminuria and other biochemical markers with presence of cardiovascular complications among patients of type-II Diabetes Mellitus. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Medicine, PNS Shifa Hospital, Karachi, Pakistan from Jan 2021 to Jun 2021 Methodology: The sample population for this study comprised of patients suffering from type-II diabetes mellitus reporting for routine follow-up visit at medicine department of our hospital. patients were divided into two groups according to presence or absence of cardiovascular complication diagnosed by treating team. Association of uric acid levels, C-reactive protein, LDL-cholesterol and albuminuria was established with presence of cardiovascular complications among the study participants. Results: Out of 208 patients of type-II diabetes mellitus included in the study, 130(63.3%) were male while 78(36.7%) were female. Mean age of the patients was 45.64±7.764 years. Mean duration of type-II Diabetes Mellitus in the study participants was 4.64±5.67 years. Out of 208 patients, 138(66.3%) patients had no cardiovascular complications while 70(33.7%) patients had any one or more cardiovascular complications. Statistical analysis revealed that hyperuricemia, raised LDL cholesterol levels and albuminuria had statistically significant association with presence of cardiovascular complications (p-value<0.05). Conclusion: Cardiovascular complications were seen in considerable number of patients managed with type-II diabetes mellitus at our hospital. Presence of albuminuria, raised serum LDL cholesterol levels and hyperuricemia emerged as risk factors for these complications among patients of type-II Diabetes mellitus.