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September 10, 2025Case Reports in OncologyOpen Access

Acute Myeloid Leukemia with BCR::ABL1+ Fusion: A report of Two Cases and Review of Literature

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Case reports describe unique presentations of acute myeloid leukemia with bcr::abl1 fusions, suggesting challenges in treatment.

One patient achieved remission after treatment with tyrosine kinase inhibitors and chemotherapy, indicating possible effective management.
A second patient exhibited poor response to therapy, with detectable bcr::abl1 transcripts at 18 months, highlighting treatment resistance.
Cytogenetic analysis revealed complexity in one case, demonstrating the challenges in diagnosing and treating acute myeloid leukemia.
Correct identification and management of acute myeloid leukemia with bcr::abl1 is critical, given the rarity and variations in response.

Dabrowski et al. (2025) studied this question.

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