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September 10, 2025Tropical Journal of Natural Product ResearchOpen Access

Ninety Days Repeated Sub-Chronic Toxicity Study of Ethanol Leaf Extract of Laggera Aurita Linn (Asteracea) In Wistar Rats

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Authors

SJSa’adatu Muhammad JuldeSBSafiya Bala BorodoAWAbubakar Sadiq Wada

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Overview

Repeated sub-chronic toxicity study finds safety of ethanol extract of laggera aurita in rats, indicating broader therapeutic potential.

Key Points

  • The study demonstrated that laggera aurita ethanol extract is generally safe at low doses of 75 mg/kg, showcasing its potential as a therapeutic agent.
  • Research findings noted a significant reduction in aspartate transaminase and urea in the liver and kidney at doses between 150-600 mg/kg compared to the control group.
  • The methodology included a 90-day chronic toxicity study on Wistar rats, with observations of no adverse changes to body weights or organ weights during the trial.
  • This study establishes the no observed adverse effect level (NOAEL) at 75 mg/kg, suggesting a favorable safety profile for low-dose administration.

Cite This Study

Julde et al. (2025) studied this question.

synapsesocial.com/papers/68c1a41654b1d3bfb60df03chttps://doi.org/10.26538/tjnpr/v9i7.56
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