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September 10, 2025Frontiers in PharmacologyOpen Access

Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis

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Authors

YLYuejiao LanCDChuan DongMWMingda Wu

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Overview

Observational analysis finds quercetin reduces epithelial-mesenchymal transition in pulmonary fibrosis, highlighting its potential anti-inflammatory benefits.

Key Points

  • Quercetin administration significantly reduced inflammation and extracellular matrix deposition in pulmonary fibrosis models.
  • In vivo studies showed that quercetin markedly decreased levels of IL-1β, MCP-1, and IL-6 in BLM-induced fibrosis.
  • The study utilized bleomycin-induced mouse models and TGF-β1-induced cell lines to evaluate quercetin's effects.
  • Modulating FSTL1 and NF-κB pathways may provide a promising therapeutic strategy for managing pulmonary fibrosis.

Cite This Study

Lan et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5e554b1d3bfb60df150https://doi.org/10.3389/fphar.2025.1594757
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