Case report highlights treatment challenges of metastatic pulmonary sarcomatoid carcinoma, indicating poor prognosis due to resistance to first-line therapies.
Pulmonary sarcomatoid carcinoma (PSC) is a rare, aggressive cancer with early metastasis and poor prognosis. Chest X-ray and computed tomography (CT) are common modalities used to detect malignancy, and the diagnosis is confirmed with tissue biopsy. There are currently no guidelines for therapy when treating this condition as it often displays resistance to typical first-line chemotherapy agents. We present a case of PSC with brain metastasis and our approach to management to remind clinicians of this rare condition and the limited choices of treatment.
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Carter et al. (2025) studied this question.
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