Randomized clinical trial compared wound healing outcomes using hyaluronic acid and corticosteroid in diabetic patients, highlighting significant efficacy differences.
Background: Diabetic patients undergoing tooth extraction are prone to many wound complications. As hyaluronic acid has anti-inflammatory properties it is suggested for wound care. Similarly, corticosteroid is also used to reduce pain and enhance the healing process. The study objective is to compare the efficacy of hyaluronic acid and corticosteroid to improve wound healing in diabetic patients. Methods: After sample size estimation of 128 via Open Epi, randomized clinical trial was performed on the diabetic patients from Oral and Maxillofacial Surgery Department in Madinah Teaching Hospital, Faisalabad from March 01, 2024 to June 30, 2024. The trial was registered at clinical trials.gov (Identifier NCT06637384). Patients were divided into three groups. Group 1 was subjected as control group; Group 2 was treated with 0.2 % Hyaluronic acid and Group 3 was treated with single dose Hy-Cortisone Injection at the extraction site. Wound healing was assessed through Landry Healing Index. Results: The results showed higher mean values of Landry healing index score for the group treated by HA. Also, statistically significant difference was found for the pairwise comparison between the groups (p value = 0.001). Corticosteroid treated group was also statistically significant on individual basis (p value < 0.05), but upon comparison HA had more promising results. Conclusion: This study concluded that upon comparison of the HA and corticosteroid treated group, HA treated group showed the highest mean Landry healing index score (4.05) among the groups, suggesting potentially better healing outcomes associated with this treatment.
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Rasheed et al. (2025) studied this question.
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