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September 10, 2025Journal of Child Neurology

Distinct Brain Magnetic Resonance Imaging (MRI) Findings Across Mucopolysaccharidosis Types: Novel Insights

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Authors

NBNisa BaşpınarHYHavva YazıcıCECenk Eraslan

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Overview

Retrospective analysis characterizes brain MRI patterns in pediatric mucopolysaccharidosis patients, revealing implications for diagnosis.

Key Points

  • MRI findings reveal distinct patterns across various mucopolysaccharidosis types, aiding in diagnosing neurologic involvement.
  • Common abnormalities identified include enlarged perivascular spaces (67.5%), ventriculomegaly (46.2%), and brain atrophy (43.8%).
  • This observational study analyzed MRI data of 80 pediatric patients diagnosed with mucopolysaccharidosis over a 12-year period.
  • Recognizing these MRI patterns can facilitate early diagnosis and therapeutic decisions for patients with mucopolysaccharidosis.

Cite This Study

Başpınar et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5f254b1d3bfb60df7f3https://doi.org/10.1177/08830738251360218
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Overview of the mucopolysaccharidoses2011 · 494 citations
  2. 2Neuropathology in Mouse Models of Mucopolysaccharidosis Type I, IIIA and IIIB2012 · 191 citations
  3. 3Leukodystrophy in Children: A Pictorial Review of MR Imaging Features2002 · 169 citations
  4. 4Brain and spine MRI features of Hunter disease: frequency, natural evolution and response to therapy2011 · 88 citations