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This is a Literature Review study.

September 10, 2025CureusOpen Access

Chimeric Antigen Receptor T-cell Therapy in the Treatment of Pediatric Acute Lymphoblastic Leukemia: Efficacy, Safety, and Future Directions

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Review synthesizes recent studies on CAR-T cell therapy's safety and efficacy in pediatric ALL, suggesting key areas for improvement.

CAR-T cell therapy achieves complete remission rates up to 100% in pediatric ALL cases, indicating strong treatment efficacy.
Safety profiles are manageable with common adverse effects like cytokine release syndrome and neurotoxicity, warranting careful monitoring.
Literature review covering 12 studies from 2014 to 2024 highlights the need for biomarkers for response prediction in pediatric patients.
Potential challenges remain in adverse effect management, particularly concerning cytokine release syndrome and neurotoxicity, signaling need for optimization.

Shamim et al. (2025) studied this question.

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