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Comparison of Outcome of Microneedling with Autologous Platelet Rich Plasma versus Microneedling with Topical Insulin in the Treatment of Post-Acne Atrophic Scars

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Randomized controlled trial compares microneedling with PRP and topical insulin in treating post-acne scars, showing PRP is more effective.

Post-treatment scar scores significantly lower in the PRP group compared to the insulin group, indicating greater efficacy.
Patient satisfaction was notably higher in the PRP group, emphasizing improved tolerability and outcomes.
This randomized controlled trial involved 60 patients aged 18–40 with post-acne atrophic scars receiving four treatment sessions.
No significant changes in blood glucose levels were observed, suggesting safety in diabetic considerations.

Ullah et al. (2025) studied this question.

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Randomized controlled trial compares microneedling with PRP and topical insulin in treating post-acne scars, showing PRP is more effective.