Dizocilpine (MK-801): The Dual Potential of a Non-Competitive NMDA Receptor Antagonist in Psychiatric Pharmacology

NMDA receptors play a very crucial role in the central nervous system. They are essential for neural transmission, synaptic plasticity, as well as learning and memory. If these receptors malfunction, it can cause various mental disorders. Deszomzipine, as a non-competitive NMDA receptor inhibitor, It has a very prominent influence on the occurrence and development of many mental illnesses. This article mainly conducts a review of it, focusing on the pharmacological characteristics of dezocepine, including its chemical structure and mechanism of action. It also focuses on exploring its application as a research tool in understanding the function of NMDA receptors and simulating related disease models, in order to provide theoretical basis for exploring its potential therapeutic drug value.