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September 10, 2025Hypertension

Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress

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Observational analysis reveals doxorubicin induces aortic stiffening via cellular senescence, suggesting senolytics may prevent it.

Aortic pulse wave velocity increased markedly with doxorubicin, indicating significant aortic stiffening.
In plasma testing, doxorubicin's effects on aortic stiffness were reversed with ganciclovir and ABT263 treatments.
Cellular senescence and SASP are critical mechanisms in doxorubicin-induced aortic stiffness, influenced by glycation stress.
This research supports the potential of senolytic therapy for mitigating cardiovascular issues from chemotherapy.

Venkatasubramanian et al. (2025) studied this question.

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