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September 10, 2025Frontiers in EndocrinologyOpen Access

Vitamin D deficiency in Hashimoto’s thyroiditis: mechanisms, immune modulation, and therapeutic implications

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Authors

WSWencong SunDalian Medical UniversityCDChao DingShengli Oilfield Central HospitalYWYichen WangGuangxi University

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Implication

Review evaluates vitamin D supplementation's effect on immune modulation in Hashimoto's thyroiditis, implying novel treatment protocols.

Key Points

  • Vitamin D deficiency elevates anti-TPO titers by 40–60%, increasing the risk of hypothyroidism.
  • Supplementation of vitamin D at 2000–4000 IU/day can reduce antibodies by 15–30% in deficient euthyroid patients.
  • Preoperative optimization of vitamin D levels lowers hypocalcemia risk by 50% after thyroid surgery.
  • Genotype-guided dosing shows that certain carriers may require lower doses for effective treatment.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68c1a77254b1d3bfb60e06c9https://doi.org/10.3389/fendo.2025.1576850
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment of Vitamin Concentrations in Patients with Hashimoto’s Thyroiditis and Their Relationships with Thyroid Function, Biochemical Status, and Anthropometric Parameters—A Preliminary Study2024 · 8 citations
  2. 2Vitamin D and thyroid function: A mendelian randomization study2024 · 13 citations
  3. 3Relation of T Cell Profile with Vitamin D Receptor and Vitamin D-Binding Protein Gene Polymorphisms in Atopy2024 · 12 citations
  4. 4Vitamin D status and current policies to achieve adequate vitamin D intake in the Nordic countries2020 · 93 citations