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September 10, 2025Experimental PhysiologyOpen Access

Bioenergetic profiles and respiratory control in mitochondrial physiology: Precision analysis of oxidative phosphorylation

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Respirometry reveals critical insights into oxidative phosphorylation capacities in cells, indicating implications for mitochondrial function.

Precision OXPHOS analysis showed convergent electron transfer enhances respiratory capacity in mitochondria.
In mouse heart and human PBMCs, OXPHOS capacity matched electron transfer capacity in many states.
Mitochondrial preparations were assessed using respiratory states and SUIT protocols for detailed analysis.
Bioenergetic profiles aid in distinguishing functional defects from metabolic adjustments in mitochondrial studies.

Timón‐Gómez et al. (2025) studied this question.

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Respirometry reveals critical insights into oxidative phosphorylation capacities in cells, indicating implications for mitochondrial function.