Multifocal Superficial Squamous Cell Carcinoma Arising in the Setting of Esophageal Intramural Pseudodiverticulosis

Esophageal intramural pseudodiverticulosis (EIPD) is a rare disease characterized endoscopically by numerous small outpouchings within the esophageal wall. While typically associated with benign symptoms such as dysphagia, EIPD has been linked to esophageal malignancy, both as a predisposing condition and associated coexisting diagnosis. However, the association is not clear. This case report details a patient with a history of EIPD who developed multifocal superficial squamous cell carcinoma in the context of high-grade dysplasia throughout the esophagus.