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September 10, 2025Annals of Surgery

Defining Biological Borderline Resectable Non-Functioning Pancreatic Neuroendocrine Tumors (NF-PanNETs)

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Authors

SPStefano PartelliGGGiovanni GuarneriPRPaola M. V. Rancoita

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Overview

Retrospective multicentric analysis identifies predictors of early recurrence in non-functioning pancreatic neuroendocrine tumors, highlighting biological borderline resectability.

Key Points

  • A predictive model identified non-functioning pancreatic neuroendocrine tumors at high risk of early recurrence.
  • The model demonstrated an AUC of 0.91 for the derivation cohort, indicating strong predictive capability.
  • Neoplastic venous thrombosis emerged as the strongest predictor of early recurrence, with a 71% probability.
  • This model serves as a preoperative tool to better stratify patients for surgery and improve outcomes.

Cite This Study

Partelli et al. (2025) studied this question.

synapsesocial.com/papers/68c1a77254b1d3bfb60e0a00https://doi.org/10.1097/sla.0000000000006867
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Nomograms for Patients With <scp>NF</scp>‐Pan‐<scp>NET</scp> After Pancreatectomy: A Retrospective Analysis Based on <scp>SEER</scp> Database2024 · 1 citations
  2. 2Prognosis analysis and recurrence prediction of patients with radical resection of pancreatic neuroendocrine neoplasms: a nomogram-based study2025
  3. 3Predictors of long-term survival for patients with pancreatic neuroendocrine neoplasm in FinPanNET: nationwide biobank study with histopathological re-evaluation2025
  4. 4Nomogram model for predicting early recurrence for resectable pancreatic cancer: A multicenter study2024 · 2 citations
  5. 5Risk Factors for Early Recurrence of Resectable Pancreatic Cancer2025 · 1 citations