Assessment of IL-12 and Liver Enzymes Levels in Serum of Some Iraqi Patients with Colon Cancer

Background: Interleukin-12 has extensively studied in colorectal cancer, but its correlation with liver enzymes is still limit. Objective: the present study aimed to assess the serum levels of Interleukin-12 and liver enzymes in Iraqi patients with colon cancer. Methods: Serum samples (90) were collected divided to 50 samples of colorectal cancer CRC patients and 40 of healthy subjects, interleukin-12 was measured using ELISA, while liver enzymes were measured spectrophotometrically and statistically analyzed. Results: The study showed significant increase (P˂0.0001) in concentration of IL-12 (304.6±26.91) pg/ml, ALP (309.9±66.84) IU/L, AST (323.5±109.9) IU/L and ALT (37.4±7.78) IU/L compared to healthy subjects (142.3±14.71 pg/ml, 165.5±38.8 IU/L, 152.6±55.34 IU/L, and 18.28±6.14 IU/L) respectively for all biomarkers. . Conclusion: Iraqi patients with CRC show elevated serum IL-12 and elevated lever enzymes, however, liver enzymes work independently and not affected by IL-12.