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This is a Case Report study (also classified as: Observational).

September 10, 2025CureusOpen Access

Misinterpretation of High-Resolution Manometry Leading to Inappropriate Treatment of Achalasia: A Diagnostic Challenge

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Case study reveals misdiagnosis of achalasia as GERD, highlighting challenges in high-resolution manometry interpretation.

Misdiagnosing achalasia as GERD can lead to inappropriate treatments, causing significant patient distress.
High-resolution manometry remains essential for diagnosing achalasia, despite potential misinterpretations impacting outcomes.
The patient misdiagnosed with GERD underwent Toupet fundoplication, which necessitated a subsequent POEM procedure for symptom relief.
Proper technique in high-resolution manometry is critical for accurate diagnosis of esophagogastric junction disorders.

Schneider et al. (2025) studied this question.

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