A Rare Case Report on Hepatic Neuroendocrine Tumour with Multifocal Hepatocellular Carcinoma

Neuroendocrine tumors (NETs) are uncommon cancers that arise from neuroendocrine cells and are typically found in the gastrointestinal tract, pancreas, and lungs. Hepatic involvement is usually due to metastases, though primary or widespread NETs of the liver are very uncommon and occasionally misdiagnosed. We describe a rare instance of a 52-year-old woman who developed lower limb edema and subsequently developed multifocal hepatocellular carcinoma, a neuroendocrine liver tumor. Imaging revealed extensive, multifocal liver lesions, which were confirmed by histopathology and immunohistochemistry. These cases are uncommon and challenging to diagnose because of the patient's atypical presentation, absence of systemic symptoms, and concurrent primary hepatic cancer. For an accurate diagnosis and appropriate treatment of rare hepatic NETs, comprehensive imaging and pathological evaluation are essential.