Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Research and Practice in Thrombosis and HaemostasisOpen Access

Prognostic Relevance of Early Clinical and Laboratory Findings in Immune-Mediated Thrombotic Thrombocytopenic purpura

View Full Paper
Ask AI
Bookmark
Share

Authors

AHAtsushi HamamuraKSKazuya SakaiTMToshiki Mushino

Discussion

Loading...

Member takes

Overview

Analysis reveals lactate dehydrogenase levels predict worse outcomes in patients with iTTP, highlighting the need for targeted monitoring.

Key Points

  • Elevated lactate dehydrogenase levels correlated with poorer prognosis in iTTP patients, emphasizing its prognostic value.
  • Among 125 patients, 15 died, with 5 deaths directly related to immune-mediated thrombotic thrombocytopenic purpura.
  • Analysis of registries included cardiac findings, neurologic symptoms, and troponin I levels, revealing limited predictive value.
  • Findings indicate that early cardiac and neurologic symptoms may not reliably predict iTTP-related death, thus redefining monitoring efforts.

Cite This Study

Hamamura et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78154b1d3bfb60e0fb2https://doi.org/10.1016/j.rpth.2025.102974
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adverse factors associated with mortality among patients with immune-mediated thrombotic thrombocytopenic purpura in Taiwan: a single-institute cohort study2026
  2. 2Analysis of clinical factors in first diagnosis of immune thrombotic thrombocytopenic purpura with report of 6 cases2024
  3. 3A Descriptive 5‐Year Analysis of the Demographics and Therapies for Patients With Immune Thrombotic Thrombocytopenic Purpura in the USA : A Multicenter Study of 390 Disease Episodes From 2017 to 20212025 · 3 citations
  4. 4IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA: PATHOPHYSIOLOGY, DIAGNOSIS AND OPEN ISSUES.2024 · 5 citations
  5. 5Relapse and beyond: Navigating the long-term clinical impacts of immune thrombotic thrombocytopenic purpura2025 · 3 citations