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September 10, 2025Cell Death and DiseaseOpen Access

Valproic acid improves the efficacy of oxaliplatin/fluoropyrimidine-based chemotherapy by targeting cancer stem cell via β-Catenin modulation in colorectal cancer

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Authors

MRMaria Serena RocaIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale"RLRita LombardiIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale"CTCristina TestaIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

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Implication

Observational analysis reveals valproic acid improves chemotherapy responses in colorectal cancer, indicating potential for targeting cancer stem cells.

Key Points

Valproic acid significantly inhibits growth and induces apoptosis in colorectal cancer cells with mutations.
Combination treatment with valproic acid and chemotherapy resulted in reduced β-Catenin levels and enhanced CSC differentiation.
In vivo models confirmed that valproic acid combined with standard chemotherapy suppressed tumor growth effectively.
This strategy may provide a novel approach to overcome chemotherapy resistance seen in metastatic colorectal cancer.

Cite This Study

Roca et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78154b1d3bfb60e1027 https://doi.org/10.1038/s41419-025-07902-8

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Implication

Observational analysis reveals valproic acid improves chemotherapy responses in colorectal cancer, indicating potential for targeting cancer stem cells.

Valproic acid improves the efficacy of oxaliplatin/fluoropyrimidine-based chemotherapy by targeting cancer stem cell via β-Catenin modulation in colorectal cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Valproic acid improves the efficacy of oxaliplatin/fluoropyrimidine-based chemotherapy by targeting cancer stem cell via β-Catenin modulation in colorectal cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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