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September 10, 2025The International Journal of Developmental BiologyOpen Access

Innervation of the masseter requires Mllt11 (Af1q/Tcf7c) function during trigeminal ganglion development

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Authors

NZNicholas W. ZinckDSDanielle Stanton‐TurcotteEWEmily A. Witt

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Overview

Conditional knockout unveils Mllt11's impact on trigeminal ganglion and motor innervation of masseter muscle.

Key Points

  • Mllt11 loss leads to altered composition of the trigeminal ganglion and reduced motor innervation.
  • Reduction of neurofilament density and neuromuscular junctions in the masseter was observed with Mllt11 inactivation.
  • Conditional knockout in Wnt1-expressing neural crest cells revealed unexpected recombination effects.
  • Findings highlight Mllt11's essential role in cranial nerve development and muscle innervation.

Cite This Study

Zinck et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78154b1d3bfb60e103bhttps://doi.org/10.1387/ijdb.240249ai
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