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April 8, 2026The International Journal of Developmental BiologyOpen Access

Dynein axonemal assembly factors ( dnaaf ) 5 and 9 are expressed in ciliated organs of zebrafish embryos

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Authors

UNUsharani NayakKSKalyani SahooRSR Swain

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Overview

Study reveals expression patterns of dnaaf5 and dnaaf9 mRNA in ciliated tissues of zebrafish embryos, suggesting their developmental roles.

Key Points

  • To investigate the expression patterns of dnaaf5 and dnaaf9 in zebrafish and assess their roles in cilia development.
  • Examined spatio-temporal expression of dnaaf5 and dnaaf9 mRNA in zebrafish embryos.
  • Identified expression in key motile ciliated tissues like Kupffer’s vesicle and pronephros.
  • Generated crispants to study functional impact of dnaaf5 and dnaaf9 during development.
  • Dnaaf5 and dnaaf9 mRNAs were found in motile ciliated organs.
  • Dnaaf5 and dnaaf9 crispants exhibited ciliopathic defects during development.
  • Results indicate functional redundancy and divergence among dynein assembly factors in vertebrates.

Cite This Study

Nayak et al. (2025) studied this question.

synapsesocial.com/papers/69d5f0d774eaea4b11a7a4a1https://doi.org/10.1387/ijdb.250162rs
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