Comprehensive analysis reveals lineage-specific maturation trajectories in the developing mouse gastric epithelium, indicating new insights into development processes.
Key Points
To investigate the temporal and spatial dynamics of epithelial maturation in the developing mouse stomach.
Conducted immunofluorescence analysis on mouse stomach tissues from mid-gestation to adulthood
Examined fetal markers, lineage-specific functional markers, and KI67 proliferation marker
Integrated functional marker expression with proliferative status
Identified distinct maturation trajectories for pit, parietal, and chief cell lineages
Noted a robust proliferative phase for parietal and chief cells before a decline
Observed region-specific timing differences in maturation between the corpus and antrum