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September 10, 2025Cardiovascular DiabetologyOpen Access

Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk

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Authors

MZMeng ZhouWSWenxiu SunYGYuhan Gao

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Overview

Cross-sectional analysis uncovers metabolic variability in patients with cardiovascular-kidney-metabolic syndrome, suggesting new biomarkers.

Key Points

  • Distinct metabolic clusters were identified through metabolomic profiling, correlating with CKM risk levels.
  • A panel of 20 metabolites showed high diagnostic performance (AUC = 0.875) for detecting advanced CKM.
  • Graphical analysis methods revealed substantial metabolic heterogeneity in CKM stage 3 patients.
  • Key metabolite signatures support individualized patient management, enhancing early risk stratification.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78154b1d3bfb60e106fhttps://doi.org/10.1186/s12933-025-02881-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolomic Profiling Reveals Interindividual Metabolic Variability and Its Association with Cardiovascular-Kidney-Metabolic Syndrome Risk2025
  2. 2Metabolomic Profiling Reveals Interindividual Metabolic Variability and Its Association with Cardiovascular-Kidney-Metabolic Disease Risk2025
  3. 3Cardiovascular-kidney-metabolic syndrome: candidate subtypes and genetic risk factors2026 · 1 citations
  4. 4Cardio-Kidney-Metabolic Syndrome: Candidate Subtypes and Genetic Risk Factors2025
  5. 5Lipidomic, plasma and flow cytometry signatures enhance the classification of patients with advanced CVD and CKM syndrome2025