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September 10, 2025BMC GastroenterologyOpen Access

Association of alterations in transcriptomics and intestinal immune responses with Bifidobacterium longum BAA2573 in improving dextran sulfate sodium-induced colitis

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Authors

WHWujuan HaoJiangnan UniversityLGLan GuJiangnan UniversityRZRenmin ZhouJiangnan University

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Implication

Observational analysis reveals enhanced immune responses and decreased pro-inflammatory cytokines in colitis, suggesting B. longum BAA2573 as a potential therapeutic agent.

Key Points

  • Bifidobacterium longum BAA2573 treatment significantly decreased cytokines TNF-α and IL-6 while increasing IL-10 and TGF-β1 levels.
  • RNA-seq identified 202 differentially expressed genes, notably involved in immune response activation and phagocytosis.
  • Immunofluorescence assays showed enhanced M2-macrophage infiltration in colonic tissues after B. longum BAA2573 treatment.
  • The results suggest that B. longum BAA2573 may regulate inflammatory pathways, indicating a promising therapeutic approach for colitis.

Cite This Study

Hao et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78154b1d3bfb60e1086https://doi.org/10.1186/s12876-025-04116-2
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