Matched cohort analysis revealed higher all-cause mortality in people with four-drug class resistance, suggesting urgent need for virological control.
People with HIV (PWH) with four-drug class resistance (4DR) had a higher risk of death than non-4DR PWH, primarily due to lower CD4 cell counts. The priority for this vulnerable population is achieving virological control to enable immune recovery.
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Giacomelli et al. (2025) studied this question.
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