Assessment of Normal Spleen Volume and Dimensions Using Computed Tomography in Relation to Age and Gender in Adults at Nepal Police Hospital

Introduction: This study aims to assess the normal dimensions and volume of the spleen in the adult Nepali population using computed tomography (CT). It further evaluates the relationship of these splenic parameters with age and gender, aiming to establish baseline reference values that can support clinical evaluation and diagnostic decision-making in abdominal imaging . Methods: This retrospective cross-sectional study included 384 adults (>18 years) who underwent abdominal CT at Nepal Police Hospital between February 2023 and February 2025, following approval from the Institutional Review Committee (Protocol No. 40-04/2082). Patients with splenic pathology, chronic illnesses, prior splenectomy, pregnancy, or inadequate imaging were excluded. Spleen dimensions (length, width, thickness) were measured, and volume was calculated. Statistical analysis assessed associations between splenic parameters, age, and gender. Result: Among 384 participants, 218 were males (56.8%) and 166 were females (43.2%). The highest representation was observed in the 28–37 and 58–67-year age groups. The mean spleen volume peaked at 179.34 cm³ in the 38–47-year group and declined progressively with age. Spleen width (r = 0.843), thickness (r = 0.839), and length (r = 0.710) showed strong positive correlations with volume, whereas craniocaudal length showed no significant association. Males exhibited higher spleen volumes in early and middle adulthood; however, the difference between genders was not statistically significant (p = 0.478). Conclusion: This study establishes normative spleen size values in adult Nepali population, highlighting age and gender differences to support accurate clinical assessment and diagnostic interpretation.